Bioorganic chemistryDeath-Associated Protein KinasesHumansDrug DesignStructure-Activity RelationshipMolecular Structure
Design, synthesis, and biological evaluation of death-associated protein kinase 1 PROTACs.
Xueyin Wu, Ruomeng Li, Wujin Tian, Jing Yao, Dongmei Chen, Tae Ho Lee, Yang Liu
Published: 202510.1016/j.bioorg.2025.109044
Abstract
Death-associated protein kinase 1 (DAPK1) serves as a crucial regulator of both autophagy and apoptosis. DAPK1 has been closely linked to cancer and various neurodegenerative diseases. Neurodegenerative disorders are chronic and progressive condition…
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