Optimization of pyrrole-2-carboxamide to develop a potent antituberculosis agent with improved physicochemical property and druggability.

MmpL3, a mycobacterial membrane protein, is essential for the transport of trehalose monomycolate, which is crucial for the formation of the M. tuberculosis outer membrane and the survival of the bacterium. Herein, we optimize our lead MmpL3 inhibito…

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