Bioorganic chemistryAnimalsCardiomegalyProto-Oncogene Proteins c-aktSignal TransductionPhosphatidylinositol 3-Kinases
Lujiao Formula attenuates cardiac hypertrophy by modulating AMPK-SIRT1 and PI3K-Akt signaling pathways.
Jianwei Zhang, Jie Shen, Wei Liu, Jiekai Hua, Fangyuan Wang, Xiaoli Shi, Guanglin Xu, Rongcai Yue, Xiaolong Wang, Li Liu
Published: 202510.1016/j.bioorg.2025.109001
Abstract
Cardiac hypertrophy (CH) represents a fundamental morphological adaptation that precedes and drives the transition to heart failure (HF). The traditional formulation Lujiao Formula (LJF) has been widely prescribed in clinical practice for more than t…
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