Biomaterials
3D culture reveals dual role of ICAM-1 in mediating tissue-specific human MSC spheroid formation & enhanced immunomodulation.
Li-Tzu Wang, Hsiu-Huan Wang, Duong Thi Thuy Doan, Yun-Fei Lin, Chien-Yu Liao, Pei-Ju Hsu, Chia-Chih Chang, Men-Luh Yen, Ko-Jiunn Liu, Huey-Kang Sytwu, B Linju Yen
Published: 202610.1016/j.biomaterials.2026.123998
Abstract
Three-dimensional (3D) in vitro culture systems may better mimic in vivo physiological conditions, and are easily accessible methods to improve therapeutic effectiveness of human mesenchymal stem cells (MSCs), which with its many sources appear to ha…
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