Biomaterials
Ultrasound-responsive renal-targeted nanoparticles deliver TAK-242 to inhibit NF-κB/NLRP3 signaling and attenuate sepsis-associated acute kidney injury.
Yingnan Guo, Ying Wang, Baoquan Wang, Shuang Peng, Na Li, Dan Zhang, Huiping Wu
Published: 202510.1016/j.biomaterials.2025.123922
Abstract
Sepsis-associated acute kidney injury (SA-AKI) remains a major clinical challenge due to the lack of effective targeted therapies. In this study, we designed ultrasound-responsive, renal-targeted nanoparticles based on serine-modified liposomes co-lo…
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