Biomaterials
Drug resistant cancer cells show increased nuclear mechanotransduction and mechanically targetable YAP-regulated vulnerability.
Miao Huang, Yinong Chen, Chenyu Liang, Om Prakash Narayan, Chase Stallings, Mu Yu, Conner Traugot, Lu Li, Keming Li, Quang Vo, Heyang Wang, Yu-Ting Chou, Lauren Cech, Daniel Parra, Laura Garzon
Published: 202510.1016/j.biomaterials.2025.123920
Abstract
Drug resistance is a leading cause of cancer treatment failure and tumor recurrence. Identifying new methods that eliminate life-threatening drug-resistant cancer cells (DRCs) can enhance tumor cell eradication and improve patient outcomes. Here we r…
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