BiomaterialsCystitisInterstitialAnimalsNerve Growth FactorTheranostic Nanomedicine
Nerve growth factor-targeting nanocluster-antibody-drug conjugates for intravesical precision theranostics of interstitial cystitis.
Zhijun Lin, Wanyan Wang, Dingxin Liu, Qiwei Liu, Zhifeng Xu, Xiangfu Zhou, Xiaodong Zhang, Yong Huang, Qi Zhao, Zhiming Wu, Jiang Yang
Published: 202610.1016/j.biomaterials.2025.123840
Abstract
Interstitial cystitis (IC) is a chronic inflammatory bladder disorder lacking timely diagnostic and therapeutic options. Here, we propose a unitary theranostic nanocluster-antibody-drug conjugate (NADC) by covalently attaching dihydroorotate dehydrog…
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