BiomaterialsPolyethylene GlycolsMetronidazoleAnimalsHumansFusobacterium nucleatum
Targeted depletion of intratumoral bacteria using PEGylated metronidazole to augment cancer treatment efficacy.
Xijun Wang, Yiran Wang, Chang Guo, Rui Guo, Wen Zuo, Caixia Liu, Jiani Wang, Chunxiao Gao, Luyao Zhang, Wei Yuan, Jie Ma
Published: 202610.1016/j.biomaterials.2025.123772
Abstract
Since the infiltration of intratumoral microbiota is associated with aggressive phenotypes of cancer, eliminating bacteria within tumors has become an attractive approach to cancer treatment. By self-assembly of PEGylated metronidazole (MTI-PEG), we…
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