Biomaterials advancesGlioblastomaHumansExtracellular MatrixHyaluronic AcidYAP-Signaling Proteins
The extracellular matrix HA promotes the YAP/hypoxia axis of glioblastoma cells on 3D agar/HA scaffolds.
Nicole Fratini, Carolina Castillo, Roberta Grillo, Stefania D'Amone, Luca Pacini, Maddalena Grieco, Maria Grazia Lolli, Sara Maria Giannitelli, Francesco Brasili, Ornella Ursini, Claudia Bearzi, Roberto Rizzi, Barbara Cortese
Published: 202610.1016/j.bioadv.2025.214664
Abstract
The tumour microenvironment of glioblastoma (GBM) as defined by mechanical heterogeneity, hypoxia, and hyaluronic acid (HA)-rich extracellular matrix (ECM), is a highly dynamic milieu which influences tumour progression and therapeutic resistance. Ye…
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