Biomaterials advancesRNASmall InterferingNanoparticlesErythrocyte MembraneMice
Novel vector for efficient siRNA delivery to lymphoblasts and melanoma based on genipin-spermine nanocarriers protected with hybrid erythrocyte membrane coating.
Giulia Della Pelle, Boštjan Markelc, Urša Čerček, Urška Živič, Mia Coupard, Jernej Šribar, Igor Križaj, Muhammad Shahid Arshad, Tim Božič, Lea Gazvoda, Boris Rogelj, Nina Kostevšek
Published: 202610.1016/j.bioadv.2025.214537
Abstract
Efficient delivery of small interfering RNA (siRNA) remains a significant challenge in gene therapy because of the instability, poor cellular uptake, and immunogenicity of the carriers. In this study, we developed a hybrid delivery system combining g…
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