Biochemical pharmacology
Effects of CYP3A4 variants and drug-drug interactions on the metabolism of fexinidazole.
Jinyu Hu, Haoxin Fu, Ruibin Li, Peiqi Wang, Jun Wu, Lu Cao, Chenjian Zhou, Ren-Ai Xu
Published: 202610.1016/j.bcp.2026.117730
Abstract
Fexinidazole is a ctirical treatment for Human African trypanosomiasis in Africa, but its metabolic characteristics are not fully understood. This study investigated the impacts of CYP3A4 genetic polymorphisms and (-)-epigallocatechin gallate (EGCG)…
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