Biochemical pharmacology
Inhibition of Ca2+-activated chloride channels by the NSAID meclofenamate for anti-diarrhea.
Qinqin Li, Huan Shi, Ping Zhou, Xiangyu Li, Yani Liu, KeWei Wang
Published: 202610.1016/j.bcp.2026.117710
Abstract
Dysfunctional calcium-activated chloride channels (CaCCs) are implicated in many pathological phenotypes and diseases. The CaCC ANO1/TMEM16A robustly expressed in epithelial cells plays an essential role in regulation of Cl- secretion and intestinal…
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