Biochemical pharmacology
DNMT1 knockdown mitigates sepsis-induced myocardial dysfunction by preventing TFAM-mediated mitochondrial DNA cytosolic escape and subsequent cGAS-STING to regulate macrophage M2 polarization.
Min Li, Yang Liu, Kuo Qu, Yu Zhang, Hailing Yang
Published: 202610.1016/j.bcp.2026.117709
Abstract
Sepsis-induced myocardial dysfunction (SIMD) is a prevalent complication of sepsis and correlates with high mortality. The study investigated the effect of inhibiting DNA methyltransferase 1 (DNMT1) on SIMD and its potential mechanism. In this study,…
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