Biochemical pharmacology
The myocardial ischemic cascade network and multi-target synergistic interventions: From molecular mechanisms to therapeutic innovations.
Lei Qi, Jia Yi, Yuntian Shen, Haiyan Jiang, Xinlei Yao, Bingqian Chen, Hualin Sun
Published: 202610.1016/j.bcp.2026.117704
Abstract
Myocardial ischemic injury involves a multi-layered pathological cascade driven by interconnected energy metabolism disorders, calcium overload, oxidative stress, mitochondrial dysfunction, and inflammatory responses. Ischemia-hypoxia impairs mitocho…
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