Natural polycyclic aromatic naphthodianthrone compound S3273 calms cytokine storm to restore acute lung injury via modulating CD39-P2X7R-IL-17A route.

CD39 participates in the process of ATP hydrolyzing into AMP, ADP and adenosine, and ATP mediates the channel-opening of P2X7 which further induces the downstream pyroptotic cell death. Current announced small-molecule CD39 enhancer are limited and t…

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