Biochemical pharmacologyAnimalsRatsOxidopamineTyrosine 3-MonooxygenasePC12 Cells
Agonism of FFA4/GPR120 activates tyrosine hydroxylase and confers neuroprotection from 6-OHDA-induced cytotoxicity in PC12 cells and in a rat 6-OHDA model of Parkinson's disease.
Farnoosh Moghaddam, Monika Binwal, Andrea J Green, Kalyn M Rambacher, Bo Jarrett Wood, Kevin S Murnane, Nader H Moniri
Published: 202610.1016/j.bcp.2026.117685
Abstract
Free-fatty acid receptor 4 (FFA4/GPR120), a G-protein-coupled receptor activated by medium to long-chain free-fatty acids (FFA) including ω-3 polyunsaturated fatty acids, regulates many metabolic and anti-inflammatory processes, and has also been lin…
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