Biochemical pharmacology
DNMT1 and DNMT3A drive hepatocellular carcinoma progression via epigenetic regulation and are inhibited by 5-azacytidine.
Jinhua Jiang, Dan Cui, Jiachang Chi, Caixia Xu, Tinghua Yan, Fang Guo
Published: 202610.1016/j.bcp.2026.117670
Abstract
Hepatocellular carcinoma (HCC) is a major global health challenge with limited therapeutic options. This study investigates the roles of DNA (deoxyribonucleic acid) methyltransferase 1 (DNMT1) and DNA methyltransferase 3 alpha (DNMT3A) in the advance…
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