Biochemical pharmacologyBiofilmsSaponinsOleanolic AcidMethicillin-Resistant Staphylococcus aureusAnimals
Saikosaponin D from Bupleurum targets SaeR to disrupt biofilm formation and pathogenic programs for the treatment of MRSA pneumonia.
Shidong Zhang, Yanhe Luan, Li Wang, Luanbiao Sun, Peitong Jiang, Dongbin Guo, Bingmei Wang, Yicheng Zhao, Yanming Jiang, Da Liu
Published: 202610.1016/j.bcp.2025.117640
Abstract
Staphylococcus aureus pneumonia, particularly methicillin-resistant Staphylococcus aureus (MRSA), remains a major clinical challenge due to biofilm formation, complex regulatory programs, and rapid acquisition of antimicrobial resistance (AMR). The S…
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