Biochemical pharmacologyAnimalsSarcopeniaMiceReceptor-Interacting Protein Serine-Threonine KinasesProteostasis
RIPK3 deficiency ameliorates diabetic sarcopenia through proteostasis regulation by suppressing inflammatory signaling and cellular stress pathways.
Jia Yi, Jitai Zhang, Xingxing Fang, Jiacheng Sun, Yuntian Shen, Xia Li, Fei Xue, Tongxin Shang, Xinlei Yao, Bingqian Chen, Hualin Sun
Published: 202610.1016/j.bcp.2025.117627
Abstract
Diabetic sarcopenia is a major complication of diabetes severely impacting patient quality of life and increasing mortality risk. Its pathogenesis remains incompletely understood and effective treatments are lacking. This study reveals the critical r…
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