Biochemical pharmacologySirtuin 1AnimalsMitophagyAutophagy-Related Protein-1 HomologRats
Agomelatine alleviates hypoxia-induced pulmonary arterial hypertension by activating mitophagy via the SIRT1/FoxO1/ULK1 signaling pathway.
Jia-Yi Zhang, Rui Zhang, Jiaqi Liu, Ling Chen, Yu-Jie Sun, Yi-Ting He, Wei-Ping Xie, Lan Wang, Hui Kong, Meng-Yu He
Published: 202610.1016/j.bcp.2025.117624
Abstract
Human melatonin receptor type 1/2 (MTR1/MTR2) are widely distributed throughout the body and play essential roles in regulating cardiovascular physiology. However, the therapeutic potential of agomelatine (AGM), a melatonin analog and nonselective MT…
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