Biochemical pharmacologyHumansInflammationNeoplasmsMolecular Docking SimulationReceptors
Discovery of a novel selective small molecule interleukin-36 receptor antagonist for inflammation and cancer.
Abdul Waheed Khan, Muhammad Haseeb, Mariya Farooq, Hongjoon Choi, Wook Kim, Hyuk-Kwon Kwon, Sangdun Choi
Published: 202610.1016/j.bcp.2025.117607
Abstract
Interleukin-36 (IL-36) is a pivotal driver of inflammatory responses in autoimmune disorders, including psoriasis, inflammatory bowel disease, and rheumatoid arthritis, and it also contributes to tumor progression. Upon activation, IL-36 triggers the…
Preview only. Read the full abstract at the source