Biochemical pharmacologyAnimalsSpider VenomsHumansNAV1.6 Voltage-Gated Sodium ChannelMolecular Docking Simulation
Singapore blue arboreal tarantula peptide Lv1a preferentially targets NaV1.6 with new world-like pharmacological mechanism.
Fernanda C Cardoso, Jessica A I Muller, Richard J Lewis
Published: 202610.1016/j.bcp.2025.117565
Abstract
Spider venom peptides evolved into bioactive entities modulating ion channels with exceptional selectivity and potency. Unlike New World tarantulas, Old World tarantulas of the family Theraphosidae from Asia, Africa and Oceania lack urticating hair a…
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