Biochemical pharmacologyHumansFlavonoidsAutophagyApoptosisTriple Negative Breast Neoplasms
Icariin inhibits autophagy and promotes apoptosis by regulating mitochondrial division in Triple-negative breast cancer.
Wen Wang, Xinyu Zhang, Shenghan Gao, Jie Liu, Siyuan Jiang, Qingjie Meng, Haomeng Zhang, Yiwen Li, Wenzhen Shi, Yonggang Lv
Published: 202610.1016/j.bcp.2025.117549
Abstract
Triple-negative breast cancer (TNBC) lacks targeted therapies and effective treatments, emphasizing the need for new drugs. Abnormal mitochondrial fission-fusion dynamics are closely linked to poor prognosis and invasiveness in TNBC. Icariin (ICA), a…
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