Biochemical pharmacologyAnimalsFerroptosisMyocardial Reperfusion InjuryMaleMice
RNF5-mediated ubiquitination of ACSL4 attenuates ferroptosis and confers cardioprotection against myocardial ischemia/reperfusion injury.
Tiankui Shuai, Yongbin Lu, Yongqiang Zhang, Min Li, Ling Chen, Pengzhong Fang, Liping Liu, Jian Liu
Published: 202610.1016/j.bcp.2025.117524
Abstract
Myocardial ischemia/reperfusion (I/R) injury remains a major clinical challenge, with ferroptosis emerging as a critical contributor to cardiomyocyte death. Notably, ring-finger protein 5 (RNF5), which functions as an E3 ubiquitin ligase that is reco…
Preview only. Read the full abstract at the source