Biochemical pharmacologyAnimalsMiceMembrane ProteinsColitisUlcerative
Toosendanin inhibits STING signaling pathway to alleviate ulcerative colitis via blocking LYN kinase and STING protein.
Shan Yang, Ting Liu, Jialiang Yang, Mengyuan Qiao, Xianli Meng, Xiaofei Shen, Jialin Yao
Published: 202610.1016/j.bcp.2025.117516
Abstract
The stimulator of interferon genes (STING) pathway plays a critical role in inflammatory diseases like ulcerative colitis (UC), yet no STING inhibitors are clinically available. Toosendanin (TSN), a bioactive triterpenoid from fruits of Melia toosend…
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