Biochemical pharmacologyHumansReactive Oxygen SpeciesMitoxantroneMitophagyMitochondria
Mitoxantrone elicits ROS-dependent elimination of dysfunctional mitochondria through mitophagy to control viability of intracellular mycobacteria in human macrophages.
Mousumi Das, Dev Kiran Nayak, Salina Patel, Ashish Kumar, Mustafeez Ali Quaderi, Pramathesh Kumar Dandsena, Lincoln Naik, Abtar Mishra, Amit Mishra, Ramandeep Singh, Sujit Kumar Bhutia, Assirbad Behura, Rohan Dhiman
Published: 202610.1016/j.bcp.2025.117512
Abstract
Autophagy plays a critical role in clearance of Mycobacterium tuberculosis. It has emerged as a promising target for host-directed therapies against drug-resistant tuberculosis (TB). This insight opens up promising therapeutic avenues, suggesting tha…
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