Biochemical pharmacologyHumansPrecursor T-Cell Lymphoblastic Leukemia-LymphomaRibosomal ProteinsJurkat CellsProtein Biosynthesis
Ribosomal protein L5 (RPL5/uL18) I60V mutation is associated to increased translation and modulates drug sensitivity in T-cell acute lymphoblastic leukemia cells.
Lorenza Bacci, Daniela Pollutri, Israt Jahan Ripa, Michael D'Andrea, Virginie Marchand, Yuri Motorin, Anne-Marie Hesse, Yohann Couté, Kamil Filipek, Marianna Penzo
Published: 202610.1016/j.bcp.2025.117497
Abstract
Somatic mutations in ribosomal proteins (RPs), including RPL5, have been reported in approximately 10 % of pediatric patients with T-cell acute lymphoblastic leukemia (T-ALL). In cancer, the incorporation of mutant RPs into ribosomes often disrupts c…
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