Biochemical pharmacologyAnimalsCarnitine O-PalmitoyltransferaseDiabetic NephropathiesHumansFatty Acids
Acetylation of CPT1A reduces fatty acid oxidation and leads to dysfunctional renal tubular mitochondria in diabetic kidney disease.
Siyao Sun, Sen Liu, Shiyan Ruan, Hongli Zhou, Xiangfei Cui, Ning Lu, Liu Hong, Miaomiao Lu
Published: 202610.1016/j.bcp.2025.117465
Abstract
Diabetic kidney disease (DKD), a major diabetic complication driving chronic and end-stage renal disease, involves disrupted proximal tubular energy metabolism. This study investigated the pathogenic role ofcarnitine palmitoyltransferase-1A (CPT1A) a…
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