Biochemical pharmacologyAnimalsMelatoninRatsInbred SHRMale
Melatonin protects vascular homeostasis by restoring PVAT redox balance in arterial hypertension.
Rosana G A Cunha, Ana Laura S Peixoto, Lauren S Coelho, Thyêssa G S Nogueira, Ana Carolina M A Santos, Júlia F de Lima, Juliano V Alves, Núbia S Lobato, Rafael M Costa
Published: 202610.1016/j.bcp.2025.117449
Abstract
Perivascular adipose tissue (PVAT) exerts vasoprotective role by releasing factors that modulate vascular tone. In arterial hypertension (AH), PVAT undergoes phenotypic alterations characterized by increased oxidative stress, inflammation, and loss o…
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