Biochemical pharmacologyHumansSTAT3 Transcription FactorCarcinomaNon-Small-Cell LungLung Neoplasms
PTGFRN promotes non-small cell lung cancer malignant progression and reprograms BCAA metabolism by activating STAT3/BCAT1 pathway.
Feiye Liu, Mengjie Li, Peng Yu, Chuanchun Han, Lili Tian, Dachuan Shen, Jing Song
Published: 202510.1016/j.bcp.2025.117445
Abstract
Prostaglandin F2 receptor negative regulator (PTGFRN) is a transmembrane protein that has been linked to the metastatic behavior of certain cancers. However, its specific function and underlying regulatory mechanisms in lung cancer remain unclear. In…
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