Biochemical pharmacologyHumansNifedipinePlacentaChlorpromazinePregnancy
Metabolism of nifedipine by placental CYP19A1 and competitive inhibition by chlorpromazine.
Tiantian Fu, Bingyi Yao, Yuanqing Guo, Yujia Yang, Junze Huang, Chenmeizi Liang, Yuanjin Zhang, Xin Wang
Published: 202510.1016/j.bcp.2025.117425
Abstract
Patients with eclampsia are treated with antihypertensive drugs such as nifedipine and sedatives like chlorpromazine. The placenta, a unique organ connecting mother and baby, can regulate the intake and export of substances and mediate their metaboli…
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