Biochemical pharmacologyHumansCell Cycle ProteinsNeoplasmsTranscription FactorsAntineoplastic Agents
Bromodomain containing protein 4 (BRD4) and cancer therapy: A glimpse at dual-target drug development.
Zixiang Li, Haoyou Wang, Bo Liu, Wei Wang
Published: 202510.1016/j.bcp.2025.117418
Abstract
Bromodomain-containing protein 4 (BRD4), a core component of the BET family, makes a contribution to transcriptional regulation and the genesis and progression of cancer. Through combining to acetylated histones, BRD4 promotes the transcription of on…
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