Biochemical pharmacologyHumansColorectal NeoplasmsDrug ResistanceNeoplasmFluorouracil
Erbin destabilization by O-GlcNAcylation promotes 5-FU resistance via homologous recombination activation in colorectal cancer.
Jianqing Zhang, Chen Liu, Yujie Tang, Kangqi Gao, Weile Xu, Jianfeng Zhang, Lianmei Zhao, Guiying Wang
Published: 202610.1016/j.bcp.2025.117400
Abstract
The emergence of 5-fluorouracil (5FU) resistance critically compromises chemotherapy efficacy in colorectal cancer (CRC). While O-GlcNAcylation-a dynamic post-translational modification linked to tumor progression-has been widely investigated, its fu…
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