Biochemical pharmacologyHumansNeovascularizationPathologicVascular Endothelial Growth Factor Receptor-2Neoplastic Stem Cells
Dual targeting of EphAs and KDR axis hampers VEGF-induced angiogenesis and glioma stem cell replication.
Alfonso Zappia, Francesca Romana Ferrari, Carmine Giorgio, Stefano Sala, Ilaria Zanotti, Simona Parrinello, Melanie P Clements, Marco Rusnati, Michela Corsini, Andrea Blesio, Riccardo Castelli, Lorenzo Guidetti, Laura Scalvini, Alessio Lodola, Massimiliano Tognolini
Published: 202510.1016/j.bcp.2025.117398
Abstract
Glioblastoma multiforme (GBM) is an aggressive and highly vascularized brain tumor with a poor prognosis and limited therapeutic options. Resistance to current treatments is largely driven by glioma stem-like cells (GSCs), a subpopulation with high t…
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