Biochemical pharmacologyRGS ProteinsTriple Negative Breast NeoplasmsHumansAnimalsCyclic AMP Response Element-Binding Protein
Targeting CREB1/p300-mediated RGS1 expression in tumor-associated macrophages improves the efficacy of anti-PD-1 therapy in triple-negative breast cancer.
Xiangyu Liu, Xingyan Ju, Ronghui Yuan, Bingxue Pan, Tongtong Feng, Jingjing Ge, Mengdi Wan, Xiaoqian Li, Fei Pan
Published: 202510.1016/j.bcp.2025.117395
Abstract
Triple-negative breast cancer (TNBC) is an aggressive phenotype of breast cancer with poor prognosis. Immunotherapy, including anti-programmed cell death protein 1 (anti-PD-1) therapy, has shown promise in treating TNBC. This study investigates the i…
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