Biochemical pharmacologyAnimalsDogsOmeprazoleOxidation-ReductionGenetic Variation
Genetic variants of cytochrome P450 2C21 identified by screening 6344 dogs influenced oxidations of the probe drug omeprazole.
Yasuhiro Uno, Koya Fukunaga, Genki Ushirozako, Norie Murayama, Keijiro Mizukami, Tomomi Aoi, Hirotaka Tomiyasu, Muneki Honnami, Hajime Tsujimoto, Masahiro Sakaguchi, Masaharu Hisasue, Taisei Mushiroda, Yukihide Momozawa, Hiroshi Yamazaki
Published: 202510.1016/j.bcp.2025.117394
Abstract
The cytochromes P450 (P450s or CYPs) are essential drug-metabolizing enzymes. In humans, the variability in metabolic activity is partly accounted for by genetic variants of the responsible P450. However, P450 genetic variants remain largely to be in…
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