Biochemical pharmacologyEpithelial-Mesenchymal TransitionFemaleHumansOvarian NeoplasmsHistone Deacetylases
Harmine inhibits ovarian cancer migration and invasion and epithelial-mesenchymal transition (EMT) by inhibiting HDAC7 to restore RECK expression.
Yin Bao, Jun Zhu, Xiaoling Mao, Mingyue Zhang, Qiang Ao, Hong Zhu, Jun Gao
Published: 202510.1016/j.bcp.2025.117391
Abstract
Harmine, a β-carboline alkaloid derived from Peganum harmala L., exhibits potent anticancer properties, including the suppression of ovarian cancer (OC) cell proliferation and metastasis. However, the underlying molecular mechanisms remain incomplete…
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