Biochemical pharmacologyAnimalsAnticonvulsantsDogsHumansRats
In Vivo/In vitro metabolic profiling and evaluation of key metabolites of QO-83, a novel KCNQ channel opener with antiepileptic potential.
Le Yang, Xiaoguang Zhang, Jiaxin Wang, Yixuan Guo, Bingsen Qi, Ziyi Liu, Jingcun Sun, Jinlong Qi
Published: 202510.1016/j.bcp.2025.117381
Abstract
KCNQ2/3 voltage-gated potassium channels constitute validated therapeutic targets for epilepsy by regulating neuronal hyperexcitability. QO-83, a novel KCNQ channel opener exhibiting potent activity and channel subtype selectivity, was undergoing pre…
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