Biochemical and biophysical research communicationsFerroptosisHumansCarcinomaHepatocellularLiver Neoplasms
Natural exosome-like nanovesicles from Smilax China rhizome induce mitophagy-dependent ferroptosis in hepatocellular carcinoma via GPX4/ACSL4 axis.
Xiayi Fang, Zicheng Liang, Zhen Zhang, Mengjuan Tao, Wenling Gong, Xiaoning Tan, Puhua Zeng
Published: 202610.1016/j.bbrc.2026.153270
Abstract
BACKGROUND: Hepatocellular carcinoma (HCC) remains challenging due to limited therapies and resistance. Mitophagy-associated ferroptosis, an iron-dependent cell death mechanism, emerges as a novel strategy, while plant-derived extracellular nanovesic…
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