Biochemical and biophysical research communicationsHydroxamic AcidsPyridonesMolecular Docking Simulationsrc Homology DomainsBiocatalysis
Characterization of the SHP2-Fumosorinone interaction using biochemical and computational approaches.
Jun Zhang, Lei Li, Ning Yang, Chen Liu, Lianyun Lin, Qi Feng, Junan Ma, Kunrong Mei, Xuesong Liu, Zhiguang Yuchi, Duqiang Luo
Published: 202610.1016/j.bbrc.2025.153235
Abstract
Src homology 2 (SH2) domain-containing protein tyrosine phosphatase-2 (SHP2) is a central modulator of proliferative signaling pathways in diverse malignancies and an important regulator of the tumor microenvironment. Owing to this dual role, SHP2 ha…
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