Biochemical and biophysical research communicationsAnimalsVasoconstrictionMonocrotalinePulmonary ArteryHumans
Enhanced Yoda1-induced vasoconstriction in pulmonary arterial smooth muscle from monocrotaline-induced pulmonary hypertensive rats.
Moe Fujiwara, Aya Yamamura, Riko Miyaki, Taiki Amano, Tatsuya Motomura, Yuki Mori, Rubii Kondo, Yoshiaki Suzuki, Hisao Yamamura
Published: 202610.1016/j.bbrc.2025.153183
Abstract
Mechanical forces such as shear stress, stretch, and pressure play critical roles in regulating vascular function. Mechanosensitive ion channels convert these mechanical stimuli into cytosolic Ca2+ signals that modulate vascular tone. The Piezo famil…
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