Biochemical and biophysical research communicationsHumansCellular SenescenceNuclear ProteinsDNA DamageCell Survival
Targeting Sestrin2 impairs survival of senescent cancer cells following DNA-damaging therapies.
Sangyeon Won, Minjoong Kim, Seungyeon Yang, Jiyoon Seo, Minbeom Ko, Eun Kyung Lee, Seung Min Jeong
Published: 202610.1016/j.bbrc.2025.153167
Abstract
Cellular senescence is a stable growth arrest commonly triggered in cancer cells by chemotherapy or radiotherapy. Although therapy-induced senescence (TIS) initially suppresses tumor proliferation, the persistence of senescent cells can promote relap…
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