Biochemical and biophysical research communicationsAnimalsHippocampusAnxietyDepressionDisease Models
A single-nucleus transcriptomic analysis reveals hippocampal neuronal alterations linked to anxiety- and depression-like behaviors in IBD model mice.
Kangcheng Luo, Mengting Zhang, Qianwen Tu, Zhao Ding, Songlin Wan, Jian Li, Youheng Wang, Tianran Chen, Daojiang Li, Qun Qian, Lu Xia
Published: 202610.1016/j.bbrc.2025.153159
Abstract
Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is a chronic inflammatory disorder that often has extraintestinal manifestations. Anxiety and depression are common in patients with IBD. Recent studies have demonstr…
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