Biochemical and biophysical research communicationsColorectal NeoplasmsHumansLactic AcidProtein BiosynthesisPeptide Elongation Factor 2
Lactate promotes mRNA translation in colorectal cancer cells through eEF2 lactylation.
Mohammad Nasiruddin Rana, Sujun Yan, Jiaqi Cao, Ye Wang, Xiang-Wei Gao
Published: 202610.1016/j.bbrc.2025.153119
Abstract
Aberrant mRNA translation contributes to tumorigenesis. Enhanced glycolysis and the resulting lactate accumulation reprogram cancer cell metabolism to support malignancy, yet how lactate modulates mRNA translation in cancer remains poorly understood.…
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