Biochemical and biophysical research communicationsHumansCarcinomaHepatocellularLiver NeoplasmsAutophagy
Nedd4 family interacting protein 1 (NDFIP1) is a novel target of PF-429242 in promoting autophagy in hepatocellular carcinoma cells.
Jiunn-Chang Lin, Tun-Sung Huang, Yan-Bin Chen, Tung-Ying Chen, Tsang-Pai Liu, Pei-Ming Yang
Published: 202610.1016/j.bbrc.2025.153065
Abstract
Our previous study demonstrates that PF-429242, an experimental membrane-bound transcription factor site-1 protease (MBTPS1) inhibitor, induces autophagy and exhibits potential anticancer activity in hepatocellular carcinoma (HCC) cells through mecha…
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