Biochemical and biophysical research communicationsAnimalsOsteoclastsGlutaminaseMiceOsteoblasts
Conditional deletion of glutaminase 1 in Tnfrsf11a-expressing cells reduces bone mass and induces postnatal growth retardation in mice.
Shintaro Terashita, Yasuhito Yahara, Jun-Dal Kim, Amane Mizutani, Hitoshi Uchida, Keisuke Yaku, Masakatsu Yamashita, Chihaya Imai, Takashi Nakagawa
Published: 202610.1016/j.bbrc.2025.153048
Abstract
Glutamine is a conditionally essential amino acid, and glutaminase 1 (GLS1) catalyzes its conversion to glutamate, which supports cellular energy metabolism and biosynthetic processes. GLS1 has been implicated in osteoclast differentiation in vitro;…
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