Biochemical and biophysical research communicationsGastrointestinal MicrobiomeAnimalsDietHigh-FatMacrophages
High-fat diet promotes colorectal tumorigenesis through gut microbiota-mediated metabolic reprogramming and M2 macrophage polarization.
Liangfei Xu, Jiajia Zhang, Yuhan Xiao, Peipei Jin, Ju Zhang
Published: 202610.1016/j.bbrc.2025.153014
Abstract
BACKGROUND: High-fat diet (HFD) drives colorectal cancer (CRC) progression through gut microbiota dysbiosis and M2 macrophage polarization, yet the microbiota-immunity crosstalk remains mechanistically unresolved. METHODS: APCmin/+ (CRC model, n = 8)…
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