Biochemical and biophysical research communicationsSodium-Potassium-Exchanging ATPaseHumansTubulinAnimalsDiabetes Mellitus
Tubulin-aldose reductase-Na+/K+-ATPase axis in diabetes: Molecular mechanisms and new pharmacological perspectives.
Juan F Rivelli Antonelli, Verónica S Santander, Alexis N Campetelli, Noelia E Monesterolo, Melisa M Balach, Gabriela Previtali, Gustavo Caro, Ayelén Nigra, César H Casale
Published: 202510.1016/j.bbrc.2025.152961
Abstract
Under high glucose conditions typical of diabetes mellitus (DM), excess glucose is shunted to the polyol pathway, where aldose reductase (AR) converts it into sorbitol contributing to osmotic imbalance and oxidative stress, especially when Na+/K+-ATP…
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