Biochemical and biophysical research communicationsAnimalsNitrosaminesLung NeoplasmsBenzo(a)pyreneMice
Comprehensive macroscopic, histopathological and molecular assessment of B[a]P and NNK-induced lung tumours in A/J mice reveals no chemopreventive efficacy of Thearubigins.
Zaid M Shaikh, Subhangi Banerji, Shruthi Sunil, Abel Zachariah, Prasad Aradhye, Amarnath Anbarasu, Jitendra Gawde, Rajiv Kumar Kaushal, Subhash Yadav, Rahul Thorat, Manoj B Mahimkar
Published: 202510.1016/j.bbrc.2025.152951
Abstract
BACKGROUND: Tobacco smoke is a complex carcinogen mixture, with Benzo[a]pyrene (B[a]P) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone NNK being key contributors to lung carcinogenesis. While chemopreventive strategies using natural compounds such…
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