Biochemical and biophysical research communicationsDexamethasoneNeutrophilsAnimalsPneumoniaPneumocystis
Dexamethasone-induced immunosuppression in Pneumocystis pneumonia reprograms neutrophil metabolism and impairs antimicrobial function.
Xiao-Xia Zhou, Yu-Xi Chen, Dong Wang, Ting Li, Heng-Mo Rong, Chao Zhang, Hu-Qin Yang, Han Sun, Kan Zhai, Zhao-Hui Tong
Published: 202510.1016/j.bbrc.2025.152889
Abstract
Dexamethasone (DEX) is a widely used immunosuppressant that predisposes hosts to opportunistic infections like Pneumocystis pneumonia (PCP). However, the precise immunological and metabolic mechanisms by which DEX alters pulmonary immunity against Pn…
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